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How TTR-FAP Symptoms Progress

Recognizing the TTR-FAP Symptoms


How symptoms progress

The onset and progression of symptoms can vary for each individual. That's why you should work closely with your healthcare professional if you are experiencing any symptoms of TTR-FAP.

Symptoms of Transthyretin Familial Amyloid Polyneuropathy (TTR-FAP) Venn diagrams

All of the symptoms of TTR-FAP may not be present at the same time. Talk with your healthcare professional about the symptoms you are experiencing and how they may impact your daily life.

Here's how symptoms can generally progress:

  • For some, sensory-motor symptoms can start in the feet with a reduced ability to sense temperature and pain, along with numbness and tingling
  • Muscle weakness and atrophy in the legs typically follow
  • Then, the arms become involved, starting at the fingertips, then traveling up the arms
  • In other patients, symptoms can start in the hands first, and then progress to the feet
  • Involuntary (autonomic) symptoms may be present at the same time as sensory-motor symptoms, or as sensory-motor symptoms worsen in the feet
  • Involuntary (autonomic) symptoms may include:
    • dizziness or fainting upon standing
    • inability to obtain or maintain an erection
    • bouts of constipation that alternate with diarrhea
    • difficulty urinating or holding urine
    • unintentional weight loss
    • abnormal (fluttering) heartbeat

TTR-FAP can also impact other parts of the body, including the kidneys, heart, and digestive system, and can interfere with their normal bodily functions. It can differ for each person.


Connect the symptoms

View an animation that shows how the sensory-motor and autonomic (involuntary)
symptoms of TTR-FAP can progress in the body.